A potentially safer, more effective chemotherapy treatment for patients with blood-related cancers, such as leukemia, who need a particular bone marrow transplant procedure is under study at the University of Arizona Health Sciences.

The procedure is known as a haploidentical (half-matched) bone marrow transplantation, or “haplo-BMT,” providng an alternative source of stem cells for patients who need a bone marrow transplant but are unable to find a perfect or near-perfect donor match for human leukocyte antigens (HLA). These HLA are proteins the immune system uses to identify cells that belong in the body and those that do not. Haplo-BMT allows for a donor to have only half the matching proteins – which can be lifesaving for the many patients who need a bone marrow transplant.

Haplo-BMT has been critically important in improving survivability for patients who lack a perfect match, a problem more prevalent among minority populations. Less than 40% of Hispanic and less than 20% of African American patients will successfully have a match in the national or international registries, compared to nearly 80% of white patients, said Emmanuel Katsanis, MD, professor in the Departments of Pediatrics, Medicine, Pathology and Immunobiology at the UArizona College of Medicine – Tucson, director of the adult and pediatric hematopoietic cellular therapy and transplant program at Banner – University Medicine and the UArizona Cancer Center, and a researcher at the UArizona Steele Children's Research Center.

For several years, Dr. Katsanis has introduced to patients the relatively new and life-saving haplo-BMT treatments. The most commonly used protocols begin with chemotherapy, followed by the transplant from the half-matched donor. After the transplant, a patient is given more chemotherapy with the drug cyclophosphamide to leave the patient stem cells and non-reactive T-cells to fight certain infections. Nevertheless, Dr. Katsanis is hopeful to uncover an even more effective chemotherapy drug.

“The current standard treatment with cyclophosphamide is effective,” Dr. Katsanis said. “However, it can also suppress the donor T-cells from attacking the leukemia. Therefore, we hypothesized other drugs may work similarly and, hopefully, better than cyclophosphamide. We found in previous research in our laboratory, which was published in the British Journal of Haematology, a journal of the British Haematology Society, that one of those drugs was bendamustine.”

Based on those findings, Dr. Katsanis wrote a Phase I clinical trial titled, “Haploidentical BMT with Post-Transplant Cyclophosphamide and Bendamustine” (ClinicalTrials.gov identifier: NCT02996773). This trial was established to test bendamustine in humans, and Dr. Katsanis recently reported preliminary results in an interim analysis published in eJHaem, another British Haematology Society journal.

“The early results from this first half of the Phase I trial have shown bendamustine is well-tolerated,” Dr. Katsanis said. “It may have advantages to recovering white blood cell counts and platelets earlier, and less susceptibility to regenerating viral infections, such as cytomegalovirus (CMV) infection. We saw a statistically significant reduction in CMV,” a noteworthy posttransplant complication.

Dr. Katsanis’ expertise in haplo-BMT also has produced promising findings for pediatric and young adult patients. He and a team of researchers recently published in Frontiers in Pediatrics the largest pediatric study of its kind to date in North America. The study demonstrated that of 21 pediatric and young adult patients who received haplo-BMT for hematlogic malignancies (cancers that affect the blood, bone marrow and lymph nodes) at Banner Children’s at Diamond Children’s Medical Center, 84% were alive with a median follow-up of more than two years.”

That survival rate is a significant result, providing hope for patients and their families.

“Haplo-BMT is expanding throughout the world,” Dr. Katsanis said. “This treatment is easier, faster and less expensive to find a donor. Now, we are trying to make it even safer and more effective for patients.”

About the University of Arizona Cancer Center

The University of Arizona Cancer Center is the only National Cancer Institute-designated Comprehensive Cancer Center with headquarters in Arizona. The UArizona Cancer Center is supported by NCI Cancer Center Support Grant No. CA023074. With primary locations at the University of Arizona in Tucson and at Dignity Health St. Joseph’s Hospital and Medical Center in Phoenix, the UArizona Cancer Center has more than a dozen research and education offices throughout the state, with more than 300 physicians and scientists working together to prevent and cure cancer. For more information http://www.cancercenter.arizona.edu.

About the University of Arizona Steele Children’s Research Center

The University of Arizona Steele Children’s Research Center is one of the prestigious Centers of Excellence in the College of Medicine – Tucson at the UArizona Health Sciences. It is the state’s only academic pediatric research center designated by the Arizona Board of Regents, and the only facility in Southern Arizona where researchers and physician-scientists are dedicated to advancing medical knowledge through basic and translational research to improve children’s health. As researchers, they seek to discover answers to children’s medical mysteries. As physician-scientists, they provide compassionate care to hospitalized patients at Banner Children’s at Diamond Children’s Medical Center and pediatric outpatient clinics throughout Tucson and the state. And, as faculty members with the UArizona Department of Pediatrics, they teach and train the next generation of pediatricians and pediatric researchers. For more information: http://www.steelecenter.arizona.edu.

About the University of Arizona Health Sciences

The University of Arizona Health Sciences is the statewide leader in biomedical research and health professions training. UArizona Health Sciences includes the Colleges of Medicine (Tucson and Phoenix), Nursing, Pharmacy, and the Mel and Enid Zuckerman College of Public Health, with main campus locations in Tucson and the Phoenix Biomedical Campus in downtown Phoenix. From these vantage points, Health Sciences reaches across the state of Arizona, the greater Southwest and around the world to provide next-generation education, research and outreach. A major economic engine, Health Sciences employs nearly 5,000 people, has approximately 4,000 students and 900 faculty members, and garners $200 million in research grants and contracts annually. For more information http://www.uahs.arizona.edu.


By Blair Willis